PIP4K2B

Across TCGA pan-cancer cohorts, PIP4K2B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIP4K2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PIP4K2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIP4K2B is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where PIP4K2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIP4K2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.686	<.001	11	view →
KIRC	Female	All	+0.491	<.001	11	view →
HNSC	All	III,IV	+0.541	<.001	10	view →
LIHC	Female	II,III,IV	+1.383	<.001	9	view →
KICH	Female	All	−1.512	<.001	8	view →
CHOL	Male	All	+2.338	<.001	5	view →
COAD	All	II,III,IV	+0.322	.003	5	view →
UCEC	All	All	−0.830	<.001	4	view →
BRCA	Female	All	−0.257	.001	4	view →
READ	All	III,IV	+0.765	.042	2	view →
STAD	Male	II,III,IV	+0.707	.034	1	view →
ESCA	All	All	+0.643	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIP4K2B–KIRP

Open the KIRP breakdown →