PIP4K2B

Across TCGA patient cohorts, PIP4K2B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4K2B-associated genes across cancer lineages are Notch1, Rad50, and ATM. Each is linked with PIP4K2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4K2B-to-partner and partner-to-PIP4K2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PIP4K2B-low versus PIP4K2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2B→partner) and Y-score (partner→PIP4K2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.226	+3.598	<.001	.001	3	2
UCEC	Rad50 →	-0.325	-3.169	<.001	<.001	3	2
UCEC	ATM →	-0.497	-1.584	.005	.036	3	2
COAD	SCD →	-0.204	-2.987	.004	.035	3	1
COAD	TSC1 →	-0.303	-2.991	.034	.036	3	1
UCEC	ERCC1 →	-0.147	-2.000	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Notch1 by PIP4K2B expression — UCEC

Explore this box plot interactively →