PIP4K2A

Across TCGA patient cohorts, PIP4K2A mutation is significantly associated with the RNA expression of many other genes, with 3,757 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4K2A-associated genes across cancer lineages are VN1R90P, C18orf25, and CFTR. Each is linked with PIP4K2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4K2A-to-partner and partner-to-PIP4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R90P grouped by PIP4K2A-low versus PIP4K2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2A→partner) and Y-score (partner→PIP4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	VN1R90P →	+0.112	+4.299	<.001	.007	3	2
UCEC	C18orf25 →	+0.409	+1.662	.001	.004	3	2
UCEC	CFTR →	-1.005	-3.968	.003	<.001	3	2
UCEC	HPGDS →	-0.402	-2.991	<.001	.001	3	2
UCEC	FAXDC2 →	-0.573	-2.263	.001	<.001	3	2
UCEC	B3GNT4 →	+0.394	+2.119	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

VN1R90P by PIP4K2A expression — BLCA

Explore this box plot interactively →