PIP

Across TCGA patient cohorts, PIP mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PIP-associated genes across cancer lineages are Gab2, N-Ras, and p38-MAPK_pT180_Y182. Each is linked with PIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP-to-partner and partner-to-PIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PIP-low versus PIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP→partner) and Y-score (partner→PIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Gab2 →	+0.477	+3.000	.036	.036	3	1
SKCM	N-Ras →	-0.196	-3.000	.012	.036	3	1
SKCM	p38-MAPK_pT180_Y182 →	-0.450	-3.000	.024	.036	3	1
SKCM	Bcl-xL →	+0.359	+3.012	<.001	.018	3	1
SKCM	MEK1_p_S217_S221 →	+0.294	+3.000	.029	.036	2	1
SKCM	PEA-15_pS116 →	+0.417	+3.000	.013	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Gab2 by PIP expression — SKCM

Explore this box plot interactively →