PIP

Across TCGA pan-cancer cohorts, PIP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PIP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIP RNA is repressed in tumor relative to normal tissue. In most cancer types PIP is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where PIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−4.317	<.001	11	view →
KICH	Female	All	+4.099	<.001	8	view →
BLCA	All	All	+1.060	.013	7	view →
LUSC	Male	II,III,IV	−1.915	<.001	6	view →
KIRP	Male	All	+1.013	<.001	6	view →
BRCA	Female	II,III,IV	−2.270	<.001	4	view →
LIHC	All	All	+0.126	.008	4	view →
PRAD	All	All	−2.271	<.001	2	view →
LUAD	Female	II,III,IV	+1.460	.044	1	view →
THCA	Male	II,III,IV	−0.478	.015	1	view →
CHOL	All	All	+0.410	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PIP–HNSC

Open the HNSC breakdown →