PINX1

Across TCGA pan-cancer cohorts, PINX1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PINX1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PINX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PINX1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where PINX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.913	0.506	<.001	29	view →
HNSC	DFS	Tertile	II,III,IV	0.632	0.934	.010	17	view →
PDAC	OS	Quartile	All	0.594	1.000	.004	13	view →
LUAD	OS	Tertile	All	0.826	0.958	.023	4	view →
GBM	OS	Median	All	0.534	0.305	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PINX1–LSCC (DFS)

Open the LSCC breakdown →