PINX1

Across TCGA patient cohorts, PINX1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,082 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PINX1-associated genes across cancer lineages are AGPAT5, PBK, and CDCA2. Each is linked with PINX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PINX1-to-partner and partner-to-PINX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PINX1 versus AGPAT5 in BRCA, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PINX1→partner) and Y-score (partner→PINX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGPAT5 →	+0.738	+0.479	.001	<.001	3	5
BRCA	PBK →	+1.460	+0.549	<.001	<.001	3	5
BRCA	CDCA2 →	+1.366	+0.537	.001	<.001	3	5
COAD	ERI1 →	+0.778	+0.648	<.001	<.001	3	4
HNSC	WRN →	+0.592	+0.323	<.001	.005	3	4
BRCA	ZCCHC24 →	-1.352	-0.537	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,082 associations by consensus.

PINX1 vs AGPAT5 — BRCA

Explore this scatter interactively →