PINLYP

Across TCGA pan-cancer cohorts, PINLYP RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PINLYP data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PINLYP RNA is associated with better overall survival. In most high-consensus cancer types, elevated PINLYP expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LGG are the cancer types where PINLYP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.440	0.253	<.001	91	view →
LUAD	OS	Median	All	0.853	0.768	<.001	67	view →
LGG	OS	Median	All	0.717	0.894	<.001	51	view →
UCEC	OS	Median	IV	0.927	0.573	.003	30	view →
STAD	OS	Median	All	0.512	0.649	.010	24	view →
ACC	OS	Tertile	III,IV	0.165	0.554	.005	20	view →
BLCA	OS	Quartile	IV	0.130	0.536	.010	18	view →
SKCM	OS	Quartile	IV	1.000	0.187	.004	10	view →
CHOL	DFS	Median	All	0.618	0.229	.023	9	view →
LUSC	OS	Median	All	0.808	0.638	.012	9	view →
THCA	OS	Median	III,IV	1.000	0.330	.007	8	view →
UCS	DFS	Median	IV	0.850	0.475	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PINLYP–HNSC (OS)

Open the HNSC breakdown →