PINLYP

Across TCGA pan-cancer cohorts, PINLYP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PINLYP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PINLYP RNA is repressed in tumor relative to normal tissue. In most cancer types PINLYP is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where PINLYP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PINLYP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.485	<.001	12	view →
KIRP	Male	II,III,IV	−1.759	<.001	11	view →
STAD	All	II,III,IV	−0.608	<.001	8	view →
LUAD	Male	All	−0.573	<.001	7	view →
UCEC	All	All	−1.980	<.001	6	view →
BLCA	Male	All	−1.008	.001	6	view →
BRCA	All	II,III,IV	−0.852	<.001	6	view →
COAD	Male	All	−0.468	.001	5	view →
KICH	Male	All	−0.957	<.001	4	view →
HNSC	Male	III,IV	+0.793	.022	3	view →
READ	Female	All	−1.058	.015	2	view →
PRAD	All	All	−0.996	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PINLYP–KIRC

Open the KIRC breakdown →