PIN4

Across TCGA patient cohorts, PIN4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,246 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIN4-associated proteins across cancer lineages are NONO, HNRNPH2, and HTATSF1. Each is linked with PIN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIN4-to-partner and partner-to-PIN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIN4 versus NONO in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN4→partner) and Y-score (partner→PIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NONO →	+0.236	+0.340	<.001	<.001	3	6
OV	HNRNPH2 →	+0.296	+0.554	<.001	<.001	3	6
LSCC	HTATSF1 →	+0.405	+0.542	<.001	<.001	3	6
GBM	ATRX →	+0.410	+0.362	<.001	<.001	2	6
GBM	ZMYM3 →	+0.274	+0.302	<.001	<.001	3	5
LSCC	RBBP7 →	+0.322	+0.414	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,246 associations by consensus.

PIN4 vs NONO — GBM

Explore this scatter interactively →