PIN1

Across TCGA patient cohorts, PIN1 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIN1-associated genes across cancer lineages are MIR4507, IGKV2OR2-1, and MIR8071-2. Each is linked with PIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIN1-to-partner and partner-to-PIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4507 grouped by PIN1-low versus PIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN1→partner) and Y-score (partner→PIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4507 →	+0.353	+3.683	.001	.003	3	2
UCEC	IGKV2OR2-1 →	+0.737	+3.104	<.001	.004	3	1
UCEC	MIR8071-2 →	+1.612	+3.712	.001	.004	3	1
UCEC	KIR3DL1 →	+0.403	+3.718	<.001	.003	3	1
UCEC	ANKRD20A4P →	+0.092	+3.602	<.001	.009	3	1
LUAD	TMOD4 →	+0.029	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MIR4507 by PIN1 expression — UCEC

Explore this box plot interactively →