PILRB

Across TCGA patient cohorts, PILRB mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PILRB-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Ku80, and Notch1. Each is linked with PILRB in more than 1 cancer types. Because this analysis shows association rather than direction, both PILRB-to-partner and partner-to-PILRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by PILRB-low versus PILRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PILRB→partner) and Y-score (partner→PILRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.645	+3.169	.004	.018	3	1
UCEC	Ku80 →	+0.237	+2.331	.026	.019	3	1
UCEC	Notch1 →	+0.140	+2.179	.027	.034	3	1
UCEC	p62 Lck ligand →	+0.412	+2.700	.004	.006	3	1
UCEC	Rad50 →	-0.257	-2.000	.018	.032	2	2
UCEC	STAT3_pY705 →	-0.394	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Acetyl-a-Tubulin-Lys40 by PILRB expression — UCEC

Explore this box plot interactively →