PIKFYVE

Across TCGA pan-cancer cohorts, PIKFYVE mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIKFYVE data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PIKFYVE mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIKFYVE expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and UCEC are the cancer types where PIKFYVE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.547	0.240	.008	9	view →
LSCC	DFS	Quartile	All	1.000	0.364	.013	8	view →
UCEC	OS	Tertile	All	0.971	0.843	.032	4	view →
PDAC	OS	Median	III,IV	0.835	0.672	.036	3	view →
HNSC	OS	Median	III,IV	1.000	0.948	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIKFYVE–GBM (OS)

Open the GBM breakdown →