PIKFYVE

Across TCGA patient cohorts, PIKFYVE mutation is significantly associated with the RNA expression of many other genes, with 4,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIKFYVE-associated genes across cancer lineages are KIF18A, INCENP, and GTSE1. Each is linked with PIKFYVE in more than 5 cancer types. Because this analysis shows association rather than direction, both PIKFYVE-to-partner and partner-to-PIKFYVE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF18A grouped by PIKFYVE-low versus PIKFYVE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIKFYVE→partner) and Y-score (partner→PIKFYVE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF18A →	+0.430	+1.267	.001	<.001	3	6
UCEC	INCENP →	+0.372	+1.230	.005	.007	3	6
UCEC	GTSE1 →	+0.598	+1.320	<.001	<.001	3	6
UCEC	GSKIP →	+0.455	+1.686	<.001	<.001	3	5
UCEC	SNX8 →	+0.318	+1.267	.001	<.001	3	5
UCEC	SNRPA1 →	+0.347	+2.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,884 associations by consensus.

KIF18A by PIKFYVE expression — UCEC

Explore this box plot interactively →