PIKFYVE

Across TCGA patient cohorts, PIKFYVE mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIKFYVE-associated genes across cancer lineages are ASNS, STAT3_pY705, and 4E-BP1. Each is linked with PIKFYVE in more than 5 cancer types. Because this analysis shows association rather than direction, both PIKFYVE-to-partner and partner-to-PIKFYVE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PIKFYVE-low versus PIKFYVE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIKFYVE→partner) and Y-score (partner→PIKFYVE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.264	+1.169	.003	.015	3	6
SKCM	STAT3_pY705 →	-0.336	-2.459	.003	.018	3	4
UCEC	4E-BP1 →	+0.340	+1.550	<.001	<.001	3	4
LUSC	PARP_cleaved →	-0.321	-2.493	.028	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.482	+3.467	<.001	.002	3	3
UCEC	eIF4E →	+0.186	+1.550	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by PIKFYVE expression — UCEC

Explore this box plot interactively →