PIKFYVE

Across TCGA cell cohorts, PIKFYVE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,425 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIKFYVE-associated GO terms across cancer lineages are 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, Peptidyl-serine autophosphorylation, and Negative regulation of gene expression, epigenetic. Each is linked with PIKFYVE in more than 18 cancer types. Because this analysis shows association rather than direction, both PIKFYVE-to-partner and partner-to-PIKFYVE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process grouped by PIKFYVE-low versus PIKFYVE-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIKFYVE→partner) and Y-score (partner→PIKFYVE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.164	+1.091	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Peptidyl-serine autophosphorylation →	+0.130	+0.824	<.001	<.001	3	19
STOMACH	Negative regulation of gene expression, epigenetic →	+0.066	+0.736	<.001	<.001	3	19
KIDNEY	Peptidyl-serine phosphorylation →	+0.108	+0.722	.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.086	+1.095	<.001	<.001	3	18
BREAST	Centrosome cycle →	+0.082	+0.781	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,425 associations by consensus.

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process by PIKFYVE expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →