PIK3R6

Across TCGA pan-cancer cohorts, PIK3R6 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PIK3R6 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PIK3R6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3R6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and SKCM are the cancer types where PIK3R6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.369	0.802	<.001	15	view →
UCEC	DFS	Median	All	0.939	0.614	.008	14	view →
SKCM	OS	Median	III,IV	0.484	0.820	.006	10	view →
CHOL	OS	Median	All	0.154	0.793	.004	9	view →
CESC	OS	Median	II,III,IV	0.227	0.759	.029	6	view →
KIRC	DFS	Median	All	0.152	0.865	<.001	6	view →
STAD	OS	Median	III,IV	0.206	0.648	.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PIK3R6–COAD (DFS)

Open the COAD breakdown →