PIK3R6

Across TCGA pan-cancer cohorts, PIK3R6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIK3R6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIK3R6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3R6 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where PIK3R6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3R6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.079	<.001	12	view →
THCA	All	III,IV	+0.638	<.001	10	view →
KIRP	Male	All	+1.170	<.001	9	view →
LIHC	Female	II,III,IV	+0.608	<.001	7	view →
HNSC	Female	II,III,IV	+0.504	.003	7	view →
STAD	All	II,III,IV	+0.653	.001	6	view →
BRCA	Female	All	+0.374	<.001	6	view →
LUSC	Male	All	−0.612	<.001	4	view →
CHOL	All	All	+1.077	<.001	3	view →
UCEC	All	All	−0.308	.041	2	view →
BLCA	All	IV	−0.462	.003	1	view →
COAD	Female	All	−0.262	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIK3R6–KIRC

Open the KIRC breakdown →