PIK3R6

Across TCGA pan-cancer cohorts, PIK3R6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIK3R6 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIK3R6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3R6 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

PDAC, GBM, and LUAD are the cancer types where PIK3R6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.669	0.832	.013	14	view →
GBM	DFS	Tertile	All	0.752	0.301	.024	2	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.523	.040	2	view →
CCRCC	DFS	Median	All	1.000	0.718	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIK3R6–PDAC (DFS)

Open the PDAC breakdown →