PIK3R6

Across TCGA patient cohorts, PIK3R6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,253 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3R6-associated genes across cancer lineages are SELL, C1QB, and C1QA. Each is linked with PIK3R6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3R6-to-partner and partner-to-PIK3R6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3R6 versus SELL in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R6→partner) and Y-score (partner→PIK3R6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SELL →	+2.568	+0.991	<.001	<.001	3	4
GBM	C1QB →	+2.202	+1.428	<.001	<.001	3	4
GBM	C1QA →	+2.351	+1.333	<.001	<.001	3	4
GBM	BCDIN3D →	-0.680	-1.075	.001	.009	3	4
GBM	TNF →	+2.193	+1.022	<.001	<.001	3	4
LUAD	AKR7A3 →	-1.681	-0.361	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,253 associations by consensus.

PIK3R6 vs SELL — GBM

Explore this scatter interactively →