PIK3R6

Across TCGA patient cohorts, PIK3R6 mutation is significantly associated with the RNA expression of many other genes, with 4,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R6-associated genes across cancer lineages are PNPLA3, ZNF330, and NEURL2. Each is linked with PIK3R6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3R6-to-partner and partner-to-PIK3R6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA3 grouped by PIK3R6-low versus PIK3R6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R6→partner) and Y-score (partner→PIK3R6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PNPLA3 →	+0.665	+2.335	.003	.003	2	4
UCEC	ZNF330 →	+0.323	+3.202	.006	<.001	3	3
COAD	NEURL2 →	-0.489	-2.321	.002	.006	3	3
UCEC	PIMREG →	+0.719	+1.665	<.001	.002	3	3
UCEC	RPA1 →	+0.611	+1.914	<.001	<.001	3	3
UCEC	WRAP53 →	+0.347	+2.637	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,111 associations by consensus.

PNPLA3 by PIK3R6 expression — COAD

Explore this box plot interactively →