PIK3R6

Across TCGA patient cohorts, PIK3R6 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R6-associated genes across cancer lineages are Cyclin-B1, FoxM1, and JNK_pT183_Y185. Each is linked with PIK3R6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3R6-to-partner and partner-to-PIK3R6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PIK3R6-low versus PIK3R6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R6→partner) and Y-score (partner→PIK3R6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.694	+3.087	<.001	<.001	3	3
UCEC	FoxM1 →	+0.264	+2.201	.002	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.155	-2.000	.005	.009	3	3
STAD	eIF4E →	+0.239	+3.000	.010	.036	3	2
UCEC	MEK1 →	+0.418	+2.201	<.001	<.001	3	2
LUSC	CD49b →	+0.444	+3.009	.009	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Cyclin-B1 by PIK3R6 expression — UCEC

Explore this box plot interactively →