PIK3R6

Across TCGA cell cohorts, PIK3R6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,653 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PIK3R6-associated GO terms across cancer lineages are Substrate adhesion-dependent cell spreading, Negative regulation of myoblast fusion, and Regulation of intracellular transport. Each is linked with PIK3R6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PIK3R6-to-partner and partner-to-PIK3R6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Substrate adhesion-dependent cell spreading grouped by PIK3R6-low versus PIK3R6-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R6→partner) and Y-score (partner→PIK3R6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Substrate adhesion-dependent cell spreading →	+0.033	+0.927	.005	.002	3	5
BREAST	Negative regulation of myoblast fusion →	+0.086	+0.038	<.001	.007	3	4
OESOPHAGUS	Regulation of intracellular transport →	+0.049	+0.032	.001	.009	3	4
BLOOD_Lymphoma	Positive regulation of viral life cycle →	+0.086	+1.837	.005	.001	3	4
BONE	Regulation of inhibitory synapse assembly →	+0.953	+0.036	.002	.003	3	4
BLOOD_Lymphoma	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.093	+1.634	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,653 associations by consensus.

Substrate adhesion-dependent cell spreading by PIK3R6 expression — BLOOD_Leukemia

Explore this box plot interactively →