PIK3R6

Across TCGA cell cohorts, PIK3R6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R6-associated genes across cancer lineages are RFPL3, COX6A2, and OR1L6. Each is linked with PIK3R6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R6-to-partner and partner-to-PIK3R6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by PIK3R6-low versus PIK3R6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R6→partner) and Y-score (partner→PIK3R6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFPL3 →	+0.044	+3.510	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ASCL3 →	+0.185	+3.726	<.001	.004	3	1
LARGE_INTESTINE	PRR23B →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR2J2 →	+0.016	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RFPL3 by PIK3R6 expression — LARGE_INTESTINE

Explore this box plot interactively →