PIK3R5

Across TCGA pan-cancer cohorts, PIK3R5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PIK3R5 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIK3R5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3R5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where PIK3R5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.626	1.000	.029	6	view →
HNSC	DFS	Median	All	1.000	0.681	.030	4	view →
LSCC	DFS	Median	II,III,IV	1.000	0.650	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PIK3R5–LUAD (OS)

Open the LUAD breakdown →