PIK3R5

Across TCGA pan-cancer cohorts, PIK3R5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PIK3R5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIK3R5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3R5 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where PIK3R5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3R5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.205	<.001	12	view →
LUAD	Male	II,III,IV	−1.396	<.001	11	view →
KIRP	Male	All	+1.403	<.001	9	view →
COAD	Female	All	−0.606	<.001	8	view →
LUSC	Male	II,III,IV	−1.867	<.001	7	view →
STAD	All	II,III,IV	+0.944	<.001	7	view →
HNSC	Female	All	+0.554	.012	3	view →
PAAD	All	All	−1.927	.024	2	view →
UCEC	All	All	−0.386	.004	2	view →
PRAD	All	All	+0.236	.048	2	view →
BRCA	Female	All	+0.212	.027	2	view →
ESCA	All	All	+1.077	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PIK3R5–KIRC

Open the KIRC breakdown →