PIK3R5

Across TCGA patient cohorts, PIK3R5 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,056 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3R5-associated proteins across cancer lineages are ARHGAP45, ARHGAP9, and PLEKHO2. Each is linked with PIK3R5 in more than 9 cancer types. Because this analysis shows association rather than direction, both PIK3R5-to-partner and partner-to-PIK3R5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3R5 versus ARHGAP45 in GBM, with a Pearson correlation of 0.80.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R5→partner) and Y-score (partner→PIK3R5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.704	+1.062	<.001	<.001	3	10
GBM	ARHGAP9 →	+0.632	+1.105	<.001	<.001	3	10
GBM	PLEKHO2 →	+0.489	+1.304	<.001	<.001	3	10
GBM	PTPN7 →	+0.536	+1.008	<.001	<.001	3	10
GBM	PTPRC →	+0.896	+1.282	<.001	<.001	3	10
OV	RASAL3 →	+0.536	+1.002	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,056 associations by consensus.

PIK3R5 vs ARHGAP45 — GBM

Explore this scatter interactively →