PIK3R5

Across TCGA patient cohorts, PIK3R5 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R5-associated genes across cancer lineages are C-Raf, PDCD4, and 4E-BP1. Each is linked with PIK3R5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3R5-to-partner and partner-to-PIK3R5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PIK3R5-low versus PIK3R5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R5→partner) and Y-score (partner→PIK3R5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C-Raf →	+0.142	+2.584	.009	.010	3	3
UCEC	PDCD4 →	-0.392	-1.584	.009	.032	3	3
UCEC	4E-BP1 →	+0.265	+2.459	.002	.018	3	3
UCEC	JNK2 →	+0.229	+2.727	<.001	.002	3	2
SKCM	MEK1 →	+0.384	+2.000	.005	.009	3	2
SKCM	MSH6 →	+0.259	+1.584	.040	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C-Raf by PIK3R5 expression — SKCM

Explore this box plot interactively →