PIK3R5

Across TCGA cell cohorts, PIK3R5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,548 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3R5-associated GO terms across cancer lineages are Protein localization to lysosome, Axoneme assembly, and Regulation of neurotransmitter secretion. Each is linked with PIK3R5 in more than 6 cancer types. Because this analysis shows association rather than direction, both PIK3R5-to-partner and partner-to-PIK3R5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to lysosome grouped by PIK3R5-low versus PIK3R5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R5→partner) and Y-score (partner→PIK3R5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein localization to lysosome →	+0.080	+0.426	<.001	.005	3	7
LUNG_NSCLC_LUSC	Axoneme assembly →	-0.040	-0.246	.006	.005	3	5
LUNG_NSCLC_LUSC	Regulation of neurotransmitter secretion →	-0.069	-0.220	.003	.001	3	5
STOMACH	Regulation of TORC1 signaling →	+0.071	+0.196	.003	.006	1	7
OVARY	Microtubule bundle formation →	-0.038	-0.476	<.001	.002	3	5
OVARY	Cytoplasmic translation →	+0.086	+0.414	.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,548 associations by consensus.

Protein localization to lysosome by PIK3R5 expression — OESOPHAGUS

Explore this box plot interactively →