PIK3R5

Across TCGA cell cohorts, PIK3R5 mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R5-associated genes across cancer lineages are PICK1, JOSD1, and IFT27. Each is linked with PIK3R5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R5-to-partner and partner-to-PIK3R5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PICK1 grouped by PIK3R5-low versus PIK3R5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R5→partner) and Y-score (partner→PIK3R5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PICK1 →	+0.631	+3.169	.004	.009	3	1
LARGE_INTESTINE	JOSD1 →	+0.523	+3.169	.005	.009	3	1
LARGE_INTESTINE	IFT27 →	+0.805	+3.588	.003	<.001	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.731	+3.502	<.001	.001	3	1
LARGE_INTESTINE	DESI1 →	+0.580	+3.321	<.001	.003	3	1
LARGE_INTESTINE	PSMC6 →	+0.578	+3.588	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

PICK1 by PIK3R5 expression — LARGE_INTESTINE

Explore this box plot interactively →