PIK3R5

Across TCGA cell cohorts, PIK3R5 mutation is significantly associated with the mutation status of many other genes, with 6,172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R5-associated genes across cancer lineages are HIVEP3, HELZ2, and CCDC73. Each is linked with PIK3R5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PIK3R5-to-partner and partner-to-PIK3R5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIVEP3 grouped by PIK3R5-low versus PIK3R5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R5→partner) and Y-score (partner→PIK3R5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HIVEP3 →	+3.210	+3.548	.001	.001	1	5
LARGE_INTESTINE	HELZ2 →	+2.080	+4.459	<.001	<.001	1	5
BLOOD_Leukemia	CCDC73 →	+5.635	+4.479	<.001	<.001	1	4
LARGE_INTESTINE	CIT →	+1.791	+2.769	<.001	<.001	1	4
BLOOD_Leukemia	ZNFX1 →	+3.465	+3.913	<.001	<.001	1	4
LARGE_INTESTINE	ZNF831 →	+3.058	+4.129	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,172 associations by consensus.

HIVEP3 by PIK3R5 expression — SKIN

Explore this box plot interactively →