PIK3R3

Across TCGA pan-cancer cohorts, PIK3R3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIK3R3 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher PIK3R3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3R3 expression acts as an unfavorable survival marker.

SARC, UCEC, and SKCM are the cancer types where PIK3R3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.022	0.861	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.232	0.705	.024	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIK3R3–SARC (OS)

Open the SARC breakdown →