PIK3R3

Across TCGA patient cohorts, PIK3R3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,142 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PIK3R3-associated proteins across cancer lineages are NFIA, SCP2, and DLG3. Each is linked with PIK3R3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIK3R3-to-partner and partner-to-PIK3R3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3R3 versus NFIA in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R3→partner) and Y-score (partner→PIK3R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFIA →	+0.446	+0.772	<.001	<.001	3	6
OV	SCP2 →	+0.711	+0.769	<.001	.007	3	5
GBM	DLG3 →	+0.483	+0.625	.001	.001	3	5
UCEC	GPC4 →	+0.615	+0.734	<.001	<.001	3	5
HNSC	ARFGEF3 →	+0.709	+0.717	<.001	.001	3	4
CCRCC	MAGI3 →	+0.406	+0.766	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,142 associations by consensus.

PIK3R3 vs NFIA — GBM

Explore this scatter interactively →