PIK3R3

Across TCGA patient cohorts, PIK3R3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R3-associated genes across cancer lineages are EGFR_pY1068, MEK1, and p38-MAPK. Each is linked with PIK3R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R3-to-partner and partner-to-PIK3R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PIK3R3-low versus PIK3R3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R3→partner) and Y-score (partner→PIK3R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.220	-2.321	.039	.034	3	1
UCEC	MEK1 →	+0.351	+1.700	.023	.044	3	1
UCEC	p38-MAPK →	-0.168	-1.700	.016	.044	3	1
UCEC	p62 Lck ligand →	+0.370	+2.999	.007	.035	3	1
UCEC	S6_pS235_S236 →	+0.377	+1.700	.040	.044	3	1
UCEC	STAT3_pY705 →	-0.453	-1.700	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by PIK3R3 expression — UCEC

Explore this box plot interactively →