PIK3R3

Across TCGA cell cohorts, PIK3R3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,084 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3R3-associated GO terms across cancer lineages are Phosphatidylinositol-3-phosphate biosynthetic process, Negative regulation of hemostasis, and Negative regulation of blood coagulation. Each is linked with PIK3R3 in more than 13 cancer types. Because this analysis shows association rather than direction, both PIK3R3-to-partner and partner-to-PIK3R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol-3-phosphate biosynthetic process grouped by PIK3R3-low versus PIK3R3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R3→partner) and Y-score (partner→PIK3R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Phosphatidylinositol-3-phosphate biosynthetic process →	+0.065	+1.483	.002	.002	3	14
SOFT_TISSUE	Negative regulation of hemostasis →	-0.179	-1.453	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of blood coagulation →	-0.179	-1.453	<.001	<.001	3	12
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.055	+1.115	.002	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of coagulation →	-0.180	-1.580	<.001	<.001	2	12
OVARY	Negative regulation of gene expression, epigenetic →	+0.056	+1.148	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,084 associations by consensus.

Phosphatidylinositol-3-phosphate biosynthetic process by PIK3R3 expression — URINARY_TRACT

Explore this box plot interactively →