PIK3R3

Across TCGA cell cohorts, PIK3R3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R3-associated genes across cancer lineages are PCARE, MOS, and OR56A5. Each is linked with PIK3R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R3-to-partner and partner-to-PIK3R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCARE grouped by PIK3R3-low versus PIK3R3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R3→partner) and Y-score (partner→PIK3R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCARE →	+0.042	+5.201	<.001	.006	3	1
CNS	MOS →	+0.047	+4.981	<.001	.008	3	1
CNS	OR56A5 →	+0.040	+6.357	<.001	<.001	3	1
CNS	KRTAP10-12 →	+0.025	+5.754	<.001	.002	3	1
CNS	KCNK16 →	+0.151	+4.981	<.001	.008	3	1
LARGE_INTESTINE	CD40 →	+1.574	+3.184	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCARE by PIK3R3 expression — BLOOD_Leukemia

Explore this box plot interactively →