PIK3R2

Across TCGA cell cohorts, PIK3R2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,138 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3R2-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, Transcription pausing by RNA polymerase II, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with PIK3R2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PIK3R2-to-partner and partner-to-PIK3R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by PIK3R2-low versus PIK3R2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R2→partner) and Y-score (partner→PIK3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of protein localization to chromatin →	+0.131	+0.917	.001	.003	3	17
BONE	Transcription pausing by RNA polymerase II →	+0.164	+1.176	<.001	<.001	3	15
STOMACH	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.092	+1.981	<.001	<.001	3	14
STOMACH	Electron transport coupled proton transport →	+0.092	+1.981	<.001	<.001	3	14
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.143	+0.992	<.001	.001	3	14
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.080	+1.062	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

Negative regulation of protein localization to chromatin by PIK3R2 expression — BONE

Explore this box plot interactively →