PIK3R2

Across TCGA cell cohorts, PIK3R2 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R2-associated genes across cancer lineages are C20orf85, IL22, and COX4I2. Each is linked with PIK3R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R2-to-partner and partner-to-PIK3R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by PIK3R2-low versus PIK3R2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R2→partner) and Y-score (partner→PIK3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	1
BLOOD_Leukemia	IL22 →	+0.025	+4.569	<.001	.003	3	1
BLOOD_Leukemia	COX4I2 →	+0.336	+3.691	<.001	.002	3	1
BLOOD_Leukemia	NPHS1 →	+0.274	+3.816	.006	.004	3	1
BLOOD_Leukemia	OR4D9 →	+0.003	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR10K1 →	+0.433	+3.234	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C20orf85 by PIK3R2 expression — BLOOD_Leukemia

Explore this box plot interactively →