PIK3IP1

Across TCGA patient cohorts, PIK3IP1 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3IP1-associated genes across cancer lineages are CA15P2, RNU6-281P, and RN7SL456P. Each is linked with PIK3IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3IP1-to-partner and partner-to-PIK3IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA15P2 grouped by PIK3IP1-low versus PIK3IP1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3IP1→partner) and Y-score (partner→PIK3IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CA15P2 →	+0.070	+5.899	<.001	.002	3	2
SKCM	RNU6-281P →	+0.373	+7.816	<.001	.008	3	2
BLCA	RN7SL456P →	+0.316	+5.038	<.001	.009	3	2
BLCA	RNU6-580P →	+0.428	+5.788	<.001	.003	3	1
BLCA	NF1P2 →	+0.021	+5.411	.002	.005	3	1
UCEC	MIR4767 →	+0.732	+2.071	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

CA15P2 by PIK3IP1 expression — BLCA

Explore this box plot interactively →