PIK3CD

Across TCGA pan-cancer cohorts, PIK3CD mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIK3CD data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIK3CD mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3CD expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where PIK3CD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.287	0.777	.004	9	view →
CCRCC	DFS	Tertile	III,IV	0.725	1.000	.009	4	view →
PDAC	OS	Quartile	III,IV	0.526	1.000	.040	4	view →
HNSC	DFS	Quartile	III,IV	1.000	0.500	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIK3CD–LUAD (OS)

Open the LUAD breakdown →