PIK3CD

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PIK3CD protein abundance is significantly associated with the RNA expression of many other genes, with 19,400 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3CD-associated genes across cancer lineages are SIRPB1, DPEP2, and LINC00528. Each is linked with PIK3CD in more than 9 cancer types. Because this analysis shows association rather than direction, both PIK3CD-to-partner and partner-to-PIK3CD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3CD versus SIRPB1 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CD→partner) and Y-score (partner→PIK3CD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCSIRPB1 →+0.846+0.456<.001<.001310
LSCCDPEP2 →+0.795+0.467<.001<.00139
LSCCLINC00528 →+0.620+0.475<.001<.00139
GBMCYTH4 →+1.130+0.578<.001<.00139
BRCASLA2 →+0.921+0.491<.001<.00139
OVTLR8 →+1.222+0.504<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,400 associations by consensus.

PIK3CD vs SIRPB1 — HNSC

Per-sample scatter of PIK3CD vs SIRPB1 in HNSC (Pearson r = 0.40).

Explore this scatter interactively →

Exploration