PIK3CD

Across TCGA patient cohorts, PIK3CD mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3CD-associated genes across cancer lineages are PCNA, Cyclin-B1, and Lck. Each is linked with PIK3CD in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3CD-to-partner and partner-to-PIK3CD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PIK3CD-low versus PIK3CD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CD→partner) and Y-score (partner→PIK3CD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.180	+1.584	.010	.017	3	3
UCEC	Cyclin-B1 →	+0.578	+2.000	.001	<.001	3	3
COAD	Lck →	+0.608	+3.025	<.001	.019	3	2
COAD	Bim →	-0.332	-2.991	.017	.036	3	2
UCEC	EGFR_pY1068 →	-0.212	-3.584	.009	.002	3	2
UCEC	ERK2 →	+0.125	+1.584	.045	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by PIK3CD expression — UCEC

Explore this box plot interactively →