PIK3CD-AS1

Across TCGA pan-cancer cohorts, PIK3CD-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PIK3CD-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIK3CD-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3CD-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ESCA are the cancer types where PIK3CD-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.459	0.245	<.001	111	view →
SKCM	OS	Median	All	0.435	0.258	<.001	105	view →
ESCA	DFS	Tertile	III,IV	0.511	0.221	.003	38	view →
OV	DFS	Median	III,IV	0.332	0.405	.022	34	view →
CESC	DFS	Quartile	All	0.849	0.649	.002	32	view →
LGG	DFS	Tertile	All	0.331	0.504	<.001	31	view →
KIRC	OS	Quartile	All	0.558	0.720	.004	30	view →
LUAD	DFS	Tertile	All	0.854	0.734	.001	28	view →
CHOL	DFS	Tertile	III,IV	0.779	0.152	.013	27	view →
DLBC	DFS	Quartile	All	0.495	0.934	.008	24	view →
UCEC	OS	Median	II,III,IV	0.798	0.903	.003	22	view →
KIRP	DFS	Quartile	All	0.427	0.941	.024	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PIK3CD-AS1–HNSC (DFS)

Open the HNSC breakdown →