PIK3CA

Across TCGA pan-cancer cohorts, PIK3CA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PIK3CA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PIK3CA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PIK3CA is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, HNSC, and COAD are the cancer types where PIK3CA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3CA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.410	<.001	9	view →
HNSC	Male	III,IV	+0.251	<.001	8	view →
COAD	All	All	−0.236	.002	5	view →
LSCC	Male	All	+0.082	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PIK3CA–LUAD

Open the LUAD breakdown →