PIK3CA

Across TCGA pan-cancer cohorts, PIK3CA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PIK3CA data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PIK3CA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3CA expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, ACC, and BLCA are the cancer types where PIK3CA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.708	0.547	<.001	82	view →
ACC	DFS	Quartile	All	0.358	0.807	<.001	58	view →
BLCA	OS	Quartile	II,III,IV	0.497	0.729	<.001	47	view →
PAAD	OS	Tertile	All	0.254	0.550	.010	31	view →
LIHC	DFS	Tertile	All	0.445	0.604	.001	22	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	20	view →
UCEC	DFS	Quartile	All	0.478	0.751	<.001	20	view →
SKCM	DFS	Tertile	All	0.266	0.155	.001	18	view →
STAD	DFS	Tertile	All	0.367	0.595	.023	14	view →
LUAD	OS	Quartile	All	0.624	0.786	.028	13	view →
CHOL	DFS	Median	All	0.605	0.237	.014	12	view →
COAD	DFS	Tertile	III,IV	0.474	0.775	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PIK3CA–KIRC (DFS)

Open the KIRC breakdown →