PIK3CA

Across TCGA patient cohorts, PIK3CA protein abundance is significantly associated with the RNA expression of many other genes, with 12,307 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3CA-associated genes across cancer lineages are DCUN1D1, UST, and TSPAN7. Each is linked with PIK3CA in more than 4 cancer types. Because this analysis shows association rather than direction, both PIK3CA-to-partner and partner-to-PIK3CA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3CA versus DCUN1D1 in LSCC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CA→partner) and Y-score (partner→PIK3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DCUN1D1 →	+0.746	+0.303	<.001	<.001	3	5
UCEC	UST →	+1.095	+0.362	<.001	<.001	3	5
UCEC	TSPAN7 →	+1.662	+0.287	<.001	.001	3	5
UCEC	H4C1 →	-1.449	-0.228	.002	.002	3	5
HNSC	ATP11B →	+0.808	+0.241	<.001	<.001	3	5
LUAD	CDT1 →	-1.037	-0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,307 associations by consensus.

PIK3CA vs DCUN1D1 — LSCC

Explore this scatter interactively →