PIK3CA

Across TCGA cell cohorts, PIK3CA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,627 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3CA-associated GO terms across cancer lineages are Negative regulation of macroautophagy, Cellular response to hydrostatic pressure, and Insulin-like growth factor receptor signaling pathway. Each is linked with PIK3CA in more than 18 cancer types. Because this analysis shows association rather than direction, both PIK3CA-to-partner and partner-to-PIK3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macroautophagy grouped by PIK3CA-low versus PIK3CA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CA→partner) and Y-score (partner→PIK3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of macroautophagy →	+0.088	+0.995	<.001	.001	3	19
LUNG_NSCLC_LUSC	Cellular response to hydrostatic pressure →	+0.134	+1.149	<.001	<.001	3	18
KIDNEY	Insulin-like growth factor receptor signaling pathway →	+0.101	+0.866	<.001	<.001	3	18
OESOPHAGUS	Cellular response to water stimulus →	+0.187	+0.975	<.001	.009	3	17
STOMACH	Negative regulation of autophagy →	+0.114	+1.080	<.001	<.001	3	15
KIDNEY	Negative regulation of protein-containing complex disassembly →	+0.098	+0.751	.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,627 associations by consensus.

Negative regulation of macroautophagy by PIK3CA expression — LUNG_SCLC

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