PIK3CA

Across TCGA cell cohorts, PIK3CA mutation is significantly associated with the RNA expression of many other genes, with 1,418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3CA-associated genes across cancer lineages are EIF4E3, H4C14, and LMF2. Each is linked with PIK3CA in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3CA-to-partner and partner-to-PIK3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4E3 grouped by PIK3CA-low versus PIK3CA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CA→partner) and Y-score (partner→PIK3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF4E3 →	+0.915	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	H4C14 →	-1.129	-1.796	<.001	.001	3	3
URINARY_TRACT	LMF2 →	+0.770	+3.169	.003	.002	3	2
URINARY_TRACT	OSGIN1 →	+1.305	+3.000	<.001	.009	3	2
BREAST	DOLK →	+0.588	+2.050	.001	<.001	3	2
URINARY_TRACT	ALG12 →	+0.560	+3.000	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,418 associations by consensus.

EIF4E3 by PIK3CA expression — LARGE_INTESTINE

Explore this box plot interactively →