PIK3C3

Across TCGA patient cohorts, PIK3C3 mutation is significantly associated with the RNA expression of many other genes, with 4,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C3-associated genes across cancer lineages are MIR6780B, RNA5SP509, and ZBTB5. Each is linked with PIK3C3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3C3-to-partner and partner-to-PIK3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780B grouped by PIK3C3-low versus PIK3C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C3→partner) and Y-score (partner→PIK3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6780B →	+0.191	+1.697	<.001	.007	3	3
BLCA	RNA5SP509 →	+0.131	+5.466	<.001	.001	3	3
UCEC	ZBTB5 →	+0.350	+2.016	.004	.001	3	3
UCEC	UBE3C →	+0.355	+1.970	.004	<.001	3	3
BLCA	RNU6-659P →	+0.381	+4.329	<.001	<.001	3	3
UCEC	SYPL1P1 →	+0.056	+1.847	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

MIR6780B by PIK3C3 expression — UCEC

Explore this box plot interactively →