PIK3C3

Across TCGA cell cohorts, PIK3C3 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PIK3C3-associated genes across cancer lineages are TFAP2D, CARTPT, and ADORA3. Each is linked with PIK3C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3C3-to-partner and partner-to-PIK3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAP2D grouped by PIK3C3-low versus PIK3C3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C3→partner) and Y-score (partner→PIK3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.077	+4.736	<.001	.009	3	2
LUNG_NSCLC_LUAD	CARTPT →	+0.011	+4.266	<.001	.004	3	2
LARGE_INTESTINE	ADORA3 →	+0.038	+3.584	.008	.006	3	2
OESOPHAGUS	TDRD15 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	BANF2 →	+0.071	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.040	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

TFAP2D by PIK3C3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →